The database below lists peer-reviewed publications that provide original data from the CHILD Cohort Study.

A database of review publications that reference CHILD Cohort Study data, without providing new data, is available here.

The database can be sorted by data field. Searches include all fields as well as the text of the papers’ abstracts, although the abstracts are not shown here.

When searching by author, use last name only.


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Author(s)YearTitleJournalKeywords
Azeez R, Ames SR, Lotoski LC, Winsor GL, Arnold CR, Galipeau Y, Pelchat M, Goguen S, Simons E, Moraes TJ, Mandhane PJ, Turvey SE, Bolotin S, Patrick DM, Bullard J, Lix LM, Doucas N, Rodriguez N, Brinkman FSL, Subbarao P, Langlois MA, Azad MB 2026

Predictors of SARS-CoV-2 anti-Spike IgG antibody levels following two COVID-19 vaccine doses among children and adults in the Canadian CHILD Cohort

Vaccine

antibodies, COVID-19 pandemic, immunology, SARS-CoV-2, vaccine, IgG
Campisi SC, Chen ZH, Simons E, Mandhane P, Moraes TJ, Turvey SE, Subbarao P, Miliku K, Korczak DJ 2026

Associations Between Dietary Patterns and Mental Health Symptoms in Early Childhood: Findings From the CHILD Cohort Study

Journal of Developmental and Behavioral Pediatrics

diet, early childhood, mental health, nutrition, despression
Chen ZH, Mousavi S, Mandhane PJ, Simons E, Subbarao P, Moraes TJ, Turvey SE, Miliku K 2026

Substituting ultra-processed food intake with minimally processed foods is associated with lower diastolic blood pressure in children

Nutrition, Metabolism & Cardiovascular Diseases

blood pressure, childhood diet, ultraprocessed foods (UFP), cardiovascular health, nutrition
Edwards K, Merrill SM, Letourneau NL, Konwar C, Gladish N, MacIsaac JL, Giesbrecht GF, Mandhane PJ, Simons E, Moraes TJ, Azad MB, Subbarao P; Turvey SE, KM, Kobor MS 2026

Early-Life DNA methylation at TRIM6 and TTC23 promoters associates with respiratory infections at one year

Pediatric Research

DNA methylation (DNAm); epigenetics; respiratory health
Jensen SK, Fischer-Rasmussen K, Eliasen A, Hesselberg LM, Brustad N, Melgaard ME, Werge T, Bybjerg-Grauholm J, Nyegaard M, Merid SK, Melen E, George E, Duan Q, Subbarao P, Schoos AM, Stokholm J, Chawes B, Pedersen CET, Bønnelykke K. 2026

From genotype to phenotype in early childhood asthma

Journal of Allergy and Clinical Immunology (JACI)

genetic risk variants; allergy; asthma; asthma endotypes; asthma phenotypes; asthma subtypes; asthma traits; asthma trajectories; genetic risk scores; single-nucleotide polymorphism; wheeze
Jiang J, Poulsen CS, Boulund U, Shah S, Trivedi U, Bhattacharyya M, Avidan U, Neumann, Dai DLY, Petersen C, Hoskinson C, Moraes TJ, Mandhane PJ, Simons E, Azad MB, Subbarao P, Bønnelykke K, Chawes B, Turvey SE, Sørensen SJ, Thorsen J, Stokholm J 2026

Early life bacteria and sibling exposure associate with restoration of the infant gut microbiome after cesarean section

Nature Communications

gut microbiome; microbiota; Cesarean delivery; C-section; birth mode; childhood asthma; respiratory health
Jopling E, Metcalfe-Roach A, Turvey SE, Mandhane P; CHILD Study investigators; Brett Finlay B, LeMoult J 2026

The infant gut microbiome and the intergenerational transmission of psychiatric risk

Brain, Behavior and Immunity

infant gut microbiome; microbiota; intergenerational transmission; internalizing symptoms; prenatal maternal stress; mental health
Kavanagh ME, Chen ZH, Tamana SK, Moraes TJ, Simons E, Turvey SE, Subbarao P, Mandhane PJ, Miliku K 2026

Ultraprocessed Food Consumption and Behavioral Outcomes in Canadian Children

JAMA Network Open

ultraprocessed foods (UPF), diet, nutrition, behavioral and emotional functioning, minimally processed foods (MPF), mental health
Liu T, Petersen C, Zhao N, Moraes TJ, Subbarao P, Simons E, Azad MB, Miliku K, Bode L, Moore B, Turvey S, Mueller NT 2026

Human Milk and Infant Gut Microbiome in Association With Infant Fecal Metabolome and Child Blood Pressure

JAMA Network Open

human milk, gut microbiome, infant fecal metabolome, systolic blood pressure (SBP), cardiometabolic health, breastmilk, formula, B infantis, nutrition
Medeleanu MV, Gill EE, Winsor GL, Azeez R, Lotoski LC, Goguen S, Humble RM, McNeil D, Patrick DM, Bolotin S, Bullard J, MacDonald SE, Simons E, Turvey SE, Moraes TJ, Subbarao P, Brinkman FSL, Azad MB 2026

Vaccination attitudes and intentions reported by Canadian children and their parents in the CHILD Cohort Study during the COVID-19 pandemic

BMC Public Health

COVID-19 vaccines; population health; vaccine hesitancy; vaccination attitudes
Mousavi S, Chen ZH, Lu Z, Santos S, L'Abbe MR, Azad MB, Mandhane PJ, Moraes TJ, Subbarao P, Turvey SE, Brook JR, Miliku K 2026

Multilevel predictors of ultra-processed food intake in Canadian preschoolers

Communications Medicine

ultraprocessed foods (UPF), diet, nutrition, family, neighbourhood environments, breastfeeding, screen time, prenatal maternal, paternal
Moyen A, Rossi A, Hart M, Simons E, Mandhane PJ, Moraes TJ, Azad MB, Turvey SE, Subbarao P, Tessier AJ, Miliku K 2026

Measuring diet intake in adolescents: Relative validation of an artificial intelligence enhanced, image assisted mobile application

Clinical Nutrition

dietary assessment; dietary intake; food diary; food record; Keenoa; nutrition; puberty; adolescence; AI
Nanishi M, Reyna ME, Pajdakovska M, Breton VL, Bédard MA, Duan Q, George E, Khan MKA, Chowdhury B, Sharma BT, Dai R, Metwali N, Perry SS, Simons E, Turvey SE, Mandhane P, Becker A, Azad MB, Sears MR, Lou W, Moraes TJ, Brook JR, Thorne PS, Subbarao P 2026

Protective effects of dog allergen and endotoxin for lung function and asthma

The Journal of Allergy and Clinical Immunology (JACI)

early-life indoor allergens; asthma; children; endotoxin; gene-environment interactions; lung function; dogs; furry pets; respiratory health
Perrett BM, Miliku K, Moraes TJ, Simons E, Mandhane P, Kebbe M. 2026

Gut microbiota responses to complementary food sources differ by milk feeding type

Clinical Nutrition

gut microbiome; host microbial interactions; human milk; infant microbiota; nutrition; diet; formula; infant feeding; breastfeeding
Turner SE, Roos L, Nickel NC, Pei J, Tamana SK, Moraes TJ, Turvey SE, Simons E, Subbarao P, Mandhane PJ, Azad MB 2026

Breastfeeding moderates the association between family socioeconomic status and child behavior scores

Frontiers in Public Health
socioeconomic status (SES), child behavior scores, mental health, breastfeeding, human milk
Zeitoun T, Chen Z, Burgner D, MacKechnie G, Huntington P, Mansell T, Longmore D, Mandhane PJ, Simons E, Turvey SE, Subbarao P, Moraes TJ, Sellen DW, Miliku K 2026

Milk fat intake, adiposity, and obesity in Canadian children: findings from the prospective Canadian CHILD Cohort Study

The American Journal of Clinical Nutrition

body composition, preclinical obesity, adiposity, nutrition, cow's milk fat, whole milk, diet
Alemu BK, Wang CC, Poon LC, Wang Y 2025

Maternal probiotics intake during pregnancy and exclusive colostrum breastfeeding are associated with a reduced risk of neonatal jaundice

BMC Medicince

Colostrum; Exclusive breastfeeding; Fetal health; Microbiome; Modifiable lifestyle intervention; Neonatal jaundice; Probiotics; human milk; nutrition
Binter AC, Doiron D, Shareck M, Pitt T, McDonald SW, Subbarao P, Fraser WD, Tough SC, Brook J, Guxens M 2025

Urban environment during pregnancy, cognitive abilities, motor function, and externalizing and internalizing symptoms at 2-5 years old in 3 Canadian birth cohorts

Environment International

Cognitive abilities; Mental health; Urban environment; cognitive development; green spaces; air pollution; pregnancy; multi-cohort
Boissiere-O'Neill T, Lazarevic N, Sly PD, Ponsonby AL, Chen A, Azad MB, Braun JM, Brook JR, Burgner D, Lanphear BP, Moraes TJ, Saffery R, Subbarao P, Turvey SE, Yolton K; CHILD investigator group; BIS investigator group; Vilcins D 2025

Phthalates and bisphenols early-life exposure, and childhood allergic conditions: a pooled analysis of cohort studies

Journal of Exposure Science & Environmental Epidemiology

allergic disease; asthma; bisphenols; phthalates; pooled analysis; wheezing; rhinitis; chemicals; respiratory health; atopy; multi-cohort
Bridgman SL, Drall KM, Lau AA, Tun HM, Morales-Lizcano NP, Huynh HQ, Mandhane PJ, Moraes TJ, Simons E, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL 2025

Infant Acid-Suppressant Medication, C. difficile Colonisation, and Childhood Body Mass Index in a Canadian Cohort

Acta Paediatrica

C. difficile; acid suppressant medication; body mass index (BMI); body weight; microbiota; infant gut microbiome
Chen ZH, Jacobson G, Reyna ME, Parvulescu P, de Souza RJ, Palmert MR, Lou W, Campisi SC, Simons E, Turvey SE, Moraes TJ, Mandhane PJ, Subbarao P, Miliku K 2025

Associations of dietary patterns and obesity development in school-aged children: results from the CHILD Cohort Study

Obesity (Silver Spring)

diet; nutrition; sex-biased obesity development; body mass index (BMI); overweight; preschoolers
Chen ZH, Mousavi S, Mandhane PJ, Simons E, Turvey SE, Moraes TJ, Subbarao P, Miliku K 2025

Ultraprocessed Food Consumption and Obesity Development in Canadian Children

JAMA Open Network

ultraprocessed foods (UPF), diet, nutrition, adiposity, obesity risk, overweight, childhood
Davias A, Verghese M, Bridgman SL, Tun HM, Field CJ, Hicks M, Pei J, Hicks A, Moraes TJ, Simons E, Turvey SE, Subbarao P, Scott JA, Mandhane PJ, Kozyrskyj AL 2025

Gut microbiota metabolites, secretory immunoglobulin A and Bayley-III cognitive scores in children from the CHILD Cohort Study

Brain, Behavior, & Immunity – Health

Bayley-III scale; infant gut microbiota; microbiome; Secretory immunoglobulin A (SIgA); cognitive development; metabolites; neurodevelopmental outcomes;
Diaz T, Danguecan A, Dominguez D, Knight A, Laskin CA, Levy DM, Jaeggi E, Misztal M, Mandhane P, Moraes T, Ng L, Silverio F, Silverman ED, Simons E, Turvey SE, Subbarao P, Hiraki LT 2025

Long-Term Outcomes of Children Born to Anti-Ro Antibody-Positive Mothers With and Without Rheumatic Disease

Arthritis Care & Research

allergy, neurodevelopmental and autoimmune diagnoses; anti-Ro antibody; maternal factors
Donald K, Serapio-Palacios A, Bozorgmehr T, Ma M, Garcia MAI, Petersen C, Mandhane PJ, Subbarao P, Moraes TJ, Simons E, Turvey S, Azad MB, Finlay BB 2025

Human milk IgA promotes normal immune development by limiting Th17-inducing Erysipelatoclostridium ramosum in the infant gut

PNAS

infant gut microbiota; microbiome; human milk; Secretory IgA (SIgA) antibody; E. ramosum microbe; allergy; immune development
Edwards K, Merrill SM, Konwar C, Jude MS, Zhuang BC, Meijer M, Navarro-Delgado E, MacIsaac JL, Mandhane P, Simons E, Moraes TJ, Azad MB, Subbarao P, Bustamante M, Vrijheid M, Turvey S, Kobor MS 2025

Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system

Communications Biology

immune cell compositions; biological sex; DNA methylation (DNAm); immune system maturation; epigenetics
Foster SA, Kile ML, Hystad P, Diamond ML, Mandhane PJ, Moraes TJ, Pei J, Scott JA, Simons E, Subbarao P, Takaro TK, Tamana SK, Turvey SE, Brook JR 2025

Organophosphate ester flame retardants and plasticizers in house dust and Child Behavior Checklist outcomes: A nested study in the Canadian CHILD Birth Cohort

Journal of Exposure Science & Environmental Epidemiology

early life exposure; epidemiology; flame retardants; indoor dust/house dust; neurodevelopment; organophosphate esters and plasticizers; emotional and behavioral problems; mental health; chemicals
Lu Z, Petersen C, Dai R, Reyna ME, Ahmadiankalati M, Sifuentes E, Dai DLY, Hoskinson C, Del Bel KL, Miliku K, Moraes TJ, Mandhane PJ, Becker AB, Azad MB, Simons E, Lou W, Ambalavanan A, Duan Q, Turvey SE, Subbarao P 2025

Early preschool wheeze trajectories are predominantly non-allergic with distinct biologic and microbiome traits

Journal of Allergy and Clinical Immunology

childhood asthma; early-life microbiome; longitudinal respiratory phenotypes; nonallergic asthma; wheeze; allergic sensitization
Medeleanu MV, Reyna ME, Dai DLY, Winsor GL, Brinkman FSL, Verma R, Nugent E, Riaz N, Simons E, Mandhane PJ, Azad MB, Turvey SE, Moraes TJ, Subbarao P 2025

Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study

Frontiers in Allergy

antibiotics; clinical epidemiology; mediation analyses; preschool asthma; respiratory tract infections
Moore LE, Tun HM, Field CJ, Mandhane PJ, Simons E, Moraes TJ, Subbarao P, Turvey SE, Hicks M, Hicks A, Kozyrskyj AL 2025

Secretory IgA modifies the association between early-life gut microbiota trajectories and childhood nonatopic wheeze

ERJ Open Research

gut microbiome; microbiota; nonatopic wheeze; secretory IgA (SIgA); breastfeeding; human milk: immune system development; respiratory health
Rossi A, Chen ZH, Ahmadiankalati M, Campisi SC, Reyna ME, Dempsey K, Jenkins D, O’Connor D, El-Sohemy A, Mandhane PJ, Simons E, Turvey SE, Moraes TJ, Lu Z, Subbarao P, Kozeta M 2025

Determining the interplay of prenatal parental BMI in shaping child BMI trajectories: the CHILD Cohort Study

International Journal of Obesity

prenatal parental body mass index (BMI); obesity risk; maternal and paternal factors; overweight
Stickley SA, Fang ZY, Ambalavanan A, Zhang Y, Zacharias AM, Petersen C, Dai D, Azad MB, Brook JR, Mandhane PJ, Simons E, Moraes TJ, Surette MG, Turvey SE, Subbarao P, Duan Q 2025

Gene-by-environment interactions modulate the infant gut microbiota in asthma and atopy

Journal of Allergy and Clinical Immunology

gene environment interactions; infant gut microbiota; microbiome; asthma; atopy; allergy; host genomics; wheeze; gut dysbiosis
Turner SE, Goguen S, Dufault B, Mayer T, Mandhane PJ, Moraes TJ, Turvey SE, Simons E, Subbarao P, Azad MB 2025

Early life predictors of child development at kindergarten: a structural equation model using a longitudinal cohort

Frontiers in Public Health

early development instrument (EDI) tool; early life exposure; family stress; school readiness; parental mental health; parenting stress; socioeconomic status (SES)
Turner SE, Roos LE, Nickel NC, Moraes TJ, Turvey SE, Simons E, Subbarao P, Robertson B, Chikuma J, Goruk S, Field C, Bode L, Pei J, Mandhane PJ, Azad MB 2025

Examining associations between human milk fatty acids, oligosaccharides, and early infant cognitive, language and motor development in the CHILD Cohort Study

Frontiers in Nutrition

cognitive development, language developement, motor development, neurodevelopment, breast milk composition, Bayley-III Scales; fatty acids; human milk oligosaccharides (HMOs); nutrition; breastfeeding
Zhang L, Dai R, Lou W, Mandhane P, Moraes TJ, Simons E, Thorne PS, To T, Turvey SE, Subbarao P, Brook JR 2025

Pets and related allergens modify the association between early life DEHP exposure and respiratory outcomes in children

Environmental Research

allergen; asthma; co-exposure; effect modification; endotoxin; interaction; furry pets; cats; dogs; phthalates; wheeze
Abrishamcar S, Zhuang BC, Thomas M, Gladish N, MacIsaac JL, Jones MJ, Simons E, Moraes TJ, Mandhane PJ, Brook JR, Subbarao P, Turvey SE, Chen E, Miller GE, Kobor MS, Hüls A 2024

Association between maternal perinatal stress and depression and infant DNA methylation in the first year of life

Translational Psychiatry

maternal perinatal stress; depression; infant DNA methylation (DNAm); mental health; prenatal; postnatal
Ahmadiankalati M, Boury H, Subbarao P, Lou W, Lu Z 2024

Bayesian additive regression trees for predicting childhood asthma in the CHILD cohort study

BMC Medical Research Methodology

wheeze, respiratory infection, food sensitization, asthma, Bayesian additive regression trees (BART), machine learning algorithms, respiratory health
Ambalavanan A, Chang L, Choi J, Zhang Y, Stickley SA, Fang ZY, Miliku K, Robertson B, Yonemitsu C, Turvey SE, Mandhane PJ, Simons E, Moraes TJ, Anand SS, Paré G, JWilliams JE, Murdoch BM, Otoo GE, Mbugua S, Kamau-Mbuthia EW, Kamundia EW, Gindola DK, Rod 2024

Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children

Nature Communications

Human milk oligosaccharides (HMOs), maternal genetics, respiratory health, human milk, breastfeeding, GWAS, diet, nutrition
Ames SR, Lotoski LC, Rodriguez L, Brodin P, Mandhane PJ, Moraes TJ, Simons E, Turvey SE, Subbarao P, Azad MB 2024

Human milk feeding practices and serum immune profiles of one-year-old infants in the CHILD birth cohort study

American Journal of Clinical Nutrition

Human milk feeding, serum immune profiles, diet, nutrition, immune biomarkers, pumped, breastfeeding
Bashar S, Tun HM, Ting JY, Hicks M, Mandhane PJ, Moraes TJ, Simons E, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL 2024

Impact of Postpartum Hospital Length-of-Stay on Infant Gut Microbiota: A Comprehensive Analysis of Vaginal and Caesarean birth

The Journal of Hospital Infection

birth mode; hospital length of stay; infant gut microbiota, microbiome, vaginal, Caesarean birth, antibiotics, breastfeeding
Becker M, Fehr K, Goguen S, Miliku K, Field C, Robertson B, Yonemitsu C, Bode L, Simons E, Marshall J, Dawod B, Mandhane P, Turvey SE, Moraes TJ, Subbarao P, Rodriguez N, Aghaeepour N, Azad MB 2024

Multimodal machine learning for modeling infant head circumference, mothers’ milk composition, and their shared environment

Scientific Reports (Nature)

machine learning, infant head circumference, human milk, environment, brain development, diet, nutrition, breastfeeding
Bergeron J, Avraam D, Calas L, Fraser W, Harris JR, Heude B, Mandhane P, Moraes TJ, Muckle G, Nader J, Séguin JR, Simons E, Subbarao P, Swertz MA, Tough S, Turvey SE, Fortier I, Rod NH, Andersen AN 2024

Stress and anxiety during pregnancy and length of gestation: a federated study using data from five Canadian and European birth cohorts

European Journal of Epidemiology

Anxiety; Data harmonization; Gestational age at birth; Multi-cohort; stress; mental health
Bridgman SL, Penfold S, Field CJ, Haqq AM, Mandhane PJ, Moraes TJ, Turvey SE, Simons E, Subbarao P, Kozyrskyj AL. 2024

Pre-labor and post-labor cesarean delivery and early childhood adiposity in the Canadian Healthy Infant Longitudinal Development (CHILD) Cohort Study

International Journal of Obesity

cesarean delivery, C-section, early childhood adiposity, overweight, body mass index (BMI), obesity, sex-specific birth delivery mode
Chehab RF, Fehr K, Moossavi S, Subbarao P, Moraes TJ, Mandhane P, de Souza RJ, Turvey SE, Khafipour E, Azad MB, Forman MR 2024

Prenatal vitamin C and fish oil supplement use are associated with human milk microbiota composition in the Canadian CHILD Cohort Study

Journal of Nutritional Science

prenatal vitamin C, fish oil supplement, human milk microbiota, microbiome, diet, nutrition, pregnancy
Debban CL, Ambalavanan A, Ghosh A, Li Z, Buschur KL, Ma Y, George E, Pistenmaa C, Bertoni AG, Oelsner EC, Michos ED, Moraes TJ, Jacobs DR Jr, Christenson S, Bhatt SP, Kaner RJ, Simons E, Turvey SE, Vameghestahbanati M, Engert JC, Kirby M, Bourbeau J, Tan 2024

Dysanapsis Genetic Risk Predicts Lung Function Across the Lifespan

American Journal of Respiratory and Critical Care Medicine

dysanapsis genetic risk, lung function, airflow obstruction; chronic obstructive pulmonary disease (COPD); lung growth and development; GWAS; respiratory health
Dekker PM, Boeren S, Saccenti E, Hettinga KA 2024

Network analysis of the proteome and peptidome sheds light on human milk as a biological system

Scientific Reports (Nature)

network analysis, proteome, peptidome, human milk, proteins, peptides
Deng WQ, Cawte N, Campbell N, Azab SM, de Souza RJ, Amel Lamri A, Morrison KM, Atkinso SA, Subbarao P, Turvey SE, Moraes TJ, Teo KK, Mandhane PJ, Azad MB, Simons E, Pare G, Anand SS 2024

DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry

eLife

maternal smoking, DNA methylation (DNAm), European, South Asian, cord blood, pregnancy, low birthweight
Fang ZY, Stickley SA, Ambalavanan A, Zhang Y, Zacharias AM, Fehr K, Moossavi S, Petersen C, Miliku K, Mandhane PJ, Simons E, Moraes TJ, Sears MR, Surette MG, Subbarao P, Turvey SE, Azad MB, Duan Q 2024

Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization

Cell Host & Microbe

human milk microbiota, microbiome, HMM, genome-wide association studies (GWAS), network analysis, asthma, allergic sensitization, atopy, early-life exposures, maternal genomics, diet, nutrition
He P, Moraes TJ, Dai D, Reyna-Vargas ME, Dai R, Mandhane P, Simons E, Azad MB, Hoskinson C, Petersen C, Del Bel KL, Turvey SE, Subbarao P, Goldenberg A, Erdman L. 2024

Early prediction of pediatric asthma in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort using machine learning

Pediatric Research

pediatric asthma, machine learning, parental asthma, antibiotic exposure, lower respiratory tract infections, wheezing, respiratory health
Hoskinson C, Medeleanu MV, Reyna ME, Dai DLY, Chowdhury B, Moraes TJ, Mandhane PJ, Simons E, Kozyrskyj AL, Azad MB, Petersen C, Turvey SE, Subbarao P. 2024

Antibiotics taken within the first year of life are linked to infant gut microbiome disruption and elevated atopic dermatitis risk

Journal of Allergy and Clinical Immunology

antibiotics, infant gut microbiome disruption, atopic dermatitis, eczema,
Lee S, Sbihi H, MacIsaac JL, Balshaw R, Ambalavanan A, Subbarao P, Mandhane PJ, Moraes TJ, Turvey SE, Duan Q, Brauer M, Brook JR, Kobor MS, Jones MJ 2024

Persistent DNA Methylation Changes across the First Year of Life and Prenatal Exposure in a Canadian Prospective Birth Study

Environmental Health Perspectives

DNA methylation (DNAm), prenatal nitrogen dioxide (NO2), traffic-related air pollution, cord blood
Lu Z, Subbarao P, Lou W 2024

A Bayesian latent class model for integrating multi-source longitudinal data: application to the CHILD cohort study

Journal of the Royal Statistical Society Series C: Applied Statistics

Bayesian model, cluster analysis, finite and infinite mixture model, longitudinal data, multi-source data
Mercer EM, Ramay HR, Moossavi S, Laforest-Lapointe I, Reyna ME, Becker AB, Simons E, Mandhane PJ, Turvey SE, Moraes TJ, Sears MR, Subbarao P, Azad MB, Arrieta MC. 2024

Divergent maturational patterns of the infant bacterial and fungal gut microbiome in the first year of life are associated with inter-kingdom community dynamics and infant nutrition

Microbiome

bacterial and fungal gut microbiome, microbiota, Alpha diversity, colonization patterns; gut fungi; gut mycobiome; inter-kingdom dynamics; microbial succession; microbiome maturation; nutrition; diet
Miliku K, Reyna ME, Medeleanu M, Dai R, Dubeau A, Lefebvre DL, Wright K, Dawod B, Beck M, Brooks E, Kobor M, Duan Q, Brook JR, Lou W, Brinkman FSL, Winsor GL, Cook J, Becker AB, Simons E, Mandhane PJ, Moraes TJ, Azad MB, Sears MR, Turvey SE, Subbarao P 2024

From Fetus to Eight: the CHILD Cohort Study

American Journal of Epidemiology

allergies; asthma; cardiovascular health; data science platform; environment; genes; growth trajectories; longitudinal prospective population-based study; mental health; microbiome; normative cohort; obesity; pediatrics
Mitina A, Khan M, Lesurf R, Yin Y, Engchuan W, Hamdan O, Pellecchia G, Trost B, Backstrom I, Guo K, Pallotto LM, Lam Doong PH, Wang Z, Nalpathamkalam T, Thiruvahindrapuram B, Papaz T, Pearson CE, Ragoussis J, Subbarao P, Azad MB, Turvey SE, Mandhane P, Mo 2024

Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathy

eBioMedicine

cardiomyopathy (CMP); long-read sequencing; tandem repeat expansions (TREs); transcription regulation
Peng Y, Tun HM, Ng SC, Wai HKF, Zhang X, Parks J, Field CJ, Mandhane PJ, Moraes TJ, Simons E, Turvey SE, Subbarao P, Brook JR, Takaro TK, Scott JA, Chan FKL, Kozyrskyj AL 2024

Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity

Gut Microbes

maternal smoking, DNA methylation (DNAm), prenatal, small body size, low birthweight, European, South Asian, epigenetics
Scime NV, Turner S, Miliku K, Simons E, Moraes TJ, Field CJ, Turvey SE, Subbarao P, Mandhane PJ, Azad MB. 2024

Association of Human Milk Fatty Acid Composition with Maternal Cardiometabolic Diseases: An Exploratory Prospective Cohort Study

Breastfeeding Medicine

diabetes mellitus; fatty acids; human milk; hypertension; lactation; preeclampsia; maternal cardiometabolic disease
Shenhav L, Fehr K, Reyna ME, Petersen C, Dai DLY, Dai R, Breton V, Rossi L, Smieja M, Simons E, Silverman MA, Levy M, Bode L, Field CJ, Marshall JS, Moraes TJ, Mandhane PJ, Turvey SE, Subbarao P, Surette SG, Azad MB 2024

Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development

Cell

nasal microbiome, gut microbiome, microbiota, human milk, respiratory health, asthma, computational biology, machine learning, microbial dynamics, microbiome development, breastfeeding
Soliman Y, Yakandawala U, Leong C, Garlock ES, Brinkman FSL, Winsor GL, Kozyrskyj AL, Mandhane PJ, Turvey SE, Moraes TJ, Subbarao P, Nickel NC, Thiessen K, Azad MB, Kelly LE 2024

The use of prescription medications and non-prescription medications during lactation in a prospective Canadian cohort study

International Breastfeeding Journal

prescription medications, non-prescription, lactation, human milk, breastfeeding
To T, Borkhoff CM, Anderson LN, Birken CS, Dell SD, Janus M, Maguire JL, Moraes TJ, Parkin PC, Subbarao P, Van Dam A, Guttman B, Terebessy E, Zhang K, Zhu J 2024

Association of factors with childhood asthma and allergic diseases using latent class analysis

Scientific Reports (Nature)

asthma, allergic diseases, latent class analysis, allergic rhinitis (AR), eczema, atopy, atopic dermatitis; environmental exposures, neighborhood factors
Turner SE, Roos L, Nickel N, Pei J, Mandhane PJ, Moraes TJ, Turvey SE, Simons E, Subbarao P, Azad MB 2024

Examining psychosocial pathways to explain the link between breastfeeding practices and child behaviour in a longitudinal cohort

BMC Public Health

breastfeeding, postpartum depression, behavioral disorders, mental health, human milk
Wiedeman AM, Miliku K, Moraes TJ, Mandhane PJ, Simons E, Subbarao P, Turvey SE, Zwicker JG, Devlin AM. 2024

Women in Canada are consuming above the upper intake level of folic acid but few are meeting dietary choline recommendations in the second trimester of pregnancy: data from the CHILD cohort study

Applied Physiology, Nutrition, and Metabolism

dietary reference intakes; fortification; one-carbon nutrients; prenatal supplements; folic acid; choline; pregnancy
Zachariasen T, Russel J, Petersen C, Vestergaard GA, Shah S, Atienza Lopez P, Passali M, Turvey SE, Sørensen SJ, Lund O, Stokholm J, Brejnrod A, Thorsen J 2024

MAGinator enables accurate profiling of de novo MAGs with strain-level phylogenies

Nature Communications

metagenome-assembled genomes (MAGs), metagenomic sequencing; microbiomes
Azab SM, Shanmuganathan M, de Souza RJ, Kroezen Z, Desai D, Williams NC, Morrison KM, Atkinson SA, Teo KK, Azad MB, Simons E, Moraes TJ, Mandhane PJ, Turvey SE, Subbarao P, Britz-McKibbin P, Anand SS 2023

Early sex-dependent differences in metabolic profiles of overweight and adiposity in young children: a cross-sectional analysis
citation

BMC Medicine

obesity, serum metabolites, overweight, adiposity, sex-specific, obesity risk
Azeez R, Lotoski L, Dubeau A, Rodriguez N, Reyna ME, Freitas T, Goguen S, Medeleanu M, Winsor GL, Brinkman FSL, Cameron EE, Roos L, Simons E, Moraes TJ, Mandhane PJ, Turvey SE, Bolotin S, Wright K, McNeil D, Patrick DM. 2023

Investigating SARS-CoV-2 infection and the health and psychosocial impact of the COVID-19 pandemic in the Canadian CHILD Cohort

Epidemiology and Health

COVID-19 pandemic ; epidemiology; immunology; SARS-CoV-2; psychosocial impacts
Bédard MA, Reyna M., Moraes TJ, Simons E, Turvey SE, Mandhane PJ, Brook JR & Subbarao P 2023

Association between gas stove use and childhood asthma in the Canadian CHILD Cohort Study

citation

Canadian Journal of Public Health

gas stove use, childhood asthma, nitrogen dioxide, fumes, respiratory health
Bruce CY, Shanmuganathan M, Azab SM, Simons E, Mandhane P, Turvey SE, Subbarao P, Azad MB, Britz-McKibbin P, Anand SS, de Souza RJ, Stearns JC. 2023

The Relationship Between Diet, Gut Microbiota, and Serum Metabolome of South Asian Infants at 1 Year
citation

The Journal of Nutrition

breastfeeding; ethnicity; gut microbiota; microbiome; infant diet; serum metabolome; human milk; microbiome; formula; nutrition
Buchholz V, Bridgman SL, Nielsen CC, Gascon M, Tun HM, Simons E, Turvey SE, Subbarao P, Takaro TK, Brook JR, Scott JA, Mandhane PJ, Kozyrskyj AL 2023

Natural Green Spaces, Sensitization to Allergens, and the Role of Gut Microbiota during Infancy
citation

mSystems

urban green space, allergens, gut microbiota, microbiome, environment, asthma, atopy, allergy, nature
Chen YY, Tun HM, Field CJ, Mandhane PJ, Moraes TJ, Simons E, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL 2023

Impact of Cesarean Delivery and Breastfeeding on Secretory Immunoglobulin A in the Infant Gut Is Mediated by Gut Microbiota and Metabolites

Metabolites

Cesarean delivery, C-section, breastfeeding, human milk, secretory immunoglobulin (SIgA), birth mode, gut microbiota, microbiome, metabolites
Dekker PM, Azad MB, Boeren S, Mandhane PJ, Moraes TJ, Simons E, Subbarao P, Turvey SE, Saccenti E, Hettinga KA 2023

Corrigendum: The human milk proteome and allergy of mother and child: exploring associations with protein abundances and protein network connectivity

Frontiers in Immunology

allergen; allergic disease; allergy development; breastmilk; differential network analysis; immunology of human milk; immunomodulatory; milk proteome;
Foster SA, Kile ML, Hystad P, Diamond ML, Jantunen LM, Mandhane PJ, Moraes TJ, Navaranjan G, Scott JA, Simons E, Subbarao P, Takaro TK, Turvey SE, Brook JR 2023

Organophosphate ester flame retardants and plasticizers in house dust and mental health outcomes among Canadian mothers: A nested prospective cohort study in CHILD

Environmental Research

organophosphate ester flame retardants, plasticizers, house dust, mental health, depression; maternal exposure, OPE, OPFR, pregnancy, stress
Gutierrez MW, Mercer EM, Moossavi S, Laforest-Lapointe I, Reyna ME, Becker AB, Simons E, Mandhane PJ, Turvey SE, Moraes TJ, Sears MR, Subbarao P, Azad MB, Arrieta M-C 2023

Maturational patterns of the infant gut mycobiome are associated with early-life body mass index
citation

Cell Reports Medicine

gut fungi, microbiome, microbiota, mycobiome, obesity, infant growth, BMI, weight gain
Hahn LM, Manny E, Dhaliwal G, Chikuma J, Robinson J, Lou W, Subbarao P, Turvey SE, Simons E, Bell RC, Letourneau N, Charlton C, Mandhane PJ 2023

Association of COVID-19 Government-Instituted Mask Mandates With Incidence of Mask Use Among Children in Alberta, Canada

JAMA Network Open

COVID-19, SARS-CoV-2, mask use, government mandate
Hoskinson C, Dai DLY, Del Bel KL, Becker AB, Moraes TJ, Mandhane PJ, Finlay BB, Simons E, Kozyrskyj AL, Azad MB, Subbarao P, Petersen C, Turvey SE 2023

Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease

Nature Communications

gut microbiota, microbiome, allergic disease, immune system, allergic sensitization
Kolsun KP, Lee S, MacIsaac JL, Subbarao P, Moraes TJ, Mandhane PJ, Turvey SE, Kobor MS, Jones MJ, Simons E 2023

DNA methylation is not associated with sensitization to or dietary introduction of highly allergenic foods in a subset of the CHILD cohort at age 1 year

Journal of Allergy and Clinical Immunology Global

DNA methylation (DNAm); diet; allergenic food; egg; epigenetic; food allergy; food introduction; food sensitization; peanut
Manus MB, Goguen SK, Azad MB 2023

The protective associations of breastfeeding with infant overweight and asthma are not dependent on maternal FUT2 secretor status

Frontiers in Nutrition

human milk; infant asthma; infant feeding; nutrition; infant weight gain; maternal secretor status; FUT2; infant overweight; asthma
Vinther JL, Cadman T, Avraam D, Ekstrøm CT, I. A. Sørensen T, Elhakeem A, Santos AC, Pinot de Moira A, Heude B , Iñiguez C, Pizzi C, Simons E, Voerman E , Corpeleijn E, Zariouh F, Santorelli G, Inskip HM , Barros H, Carson J, Harris JR, Nader JL, Ronka 2023

Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies
citation

PLoS Medicine

gestational age at birth; body size; BMI
Zhang L , Navaranjan G, Takaro TK, Bernstein S, Jantunen L, Lou W, Mandhane PJ, Moraes TJ, Scott JA, Simons E, Turvey SE, Subbarao P, Brook JR 2023

Di-(2-Ethylhexyl) Phthalate (DEHP) in House Dust in Canadian Homes: Behaviors and Associations with Housing Characteristics and Consumer Products

citation

Indoor Air

Di-(2-Ethylhexyl) phthalate (DEHP); house dust; urine metabolites; vinyl flooring, furniture, toys
Zhao X, Bridgman SL, Drall KM, Tun HM, Mandhane PJ, Moraes TJ, Simons E, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL 2023

Infant Vitamin D Supplements, Fecal Microbiota and Their Metabolites at 3 Months of Age in the CHILD Study Cohort

Biomolecules

1,2-propanediol; Cholecalciferol; breastfeeding; glycerol; microbiome; supplementation; Vitamin D; microbiota metabolites
Akhabir L, Stringer R, Desai D, Mandhane PJ, Azad MB, Moraes TJ, Subbarao P, Turvey SE, Paré G, Anand SS 2022

DNA methylation changes in cord blood and the developmental origins of health and disease – a systematic review and replication study
citation

BMC Genomics

DNA methylation (DNAm); cord blood; maternal smoking during pregnancy; gestational age; multi-cohort
Bedard P, Winsor GL, Garlock ES, Azad MB, Becker AB, Mandhane PJ, Moraes TJ, Sears MR, Turvey SE, Subbarao P, Brinkman FSL, Kozyrskyj AL. 2022

From Prescription Drugs to Natural Health Products: Medication Use in Canadian Infants
citation

Children (Basel)

prescription drugs; natural health products: medication use; family medicine; general practice; pharmaceutical industry; pediatrics; pharmacy; primary care
Bridgman SL, Malmuthuge N, Mandal R, Field CJ, Haqq AM, Mandhane PJ, Moraes TJ, Turvey SE, Simons E, Subbarao P, Scott JA, Wishart DS, Kozyrskyj AL. 2022

Childhood body mass index and associations with infant gut metabolites and secretory IgA: findings from a prospective cohort study
citation

International Journal of Obesity

body mass index (BMI); infant gut metabolites; secretory IgA (SIgA); gut microbiota; microbiome; obesity; overweight; exclusive breastfeeding
Dai DLY, Petersen C, Hoskinson C, Del Bel KL, Becker AB, Moraes TJ, Mandhane PJ, Finlay BB, Simons E, Kozyrskyj AL, Patrick DM, Subbarao P, Bode L,Azad MB, Turvey SE 2022

Breastfeeding enrichment of B. longum subsp. infantis mitigates the effect of antibiotics on the microbiota and childhood asthma risk
citation

Med

breastfeeding; B. longum subsp. infantis; antibiotics; microbiota; microbiome; childhood asthma risk; human milk; diet; nutrition
Dai R, Miliku K, Gaddipati S, Choi J, Ambalavanan A, Tran MM, Reyna M, Sbihi H, Lou W, Parvulescu P, Lefebvre DL, Becker AB, Azad MB, Mandhane PJ, Turvey SE, Duan Q, Moraes TJ, Sears MR, Subbarao P 2022

Wheeze trajectories: Determinants and outcomes in the CHILD Cohort Study
citation

Journal of Allergy and Clinical Immunology

wheeze; asthma; early-life determinants; genetic risk; lung function; pediatrics; parental factors
Dekker PM, Azad MB, Boeren S, Mandhane PJ, Moraes TJ, Simons E, Subbarao P, Turvey SE, Saccenti E, Hettinga KA 2022

The human milk proteome and allergy of mother and child: Exploring associations with protein abundances and protein network connectivity
citation

Frontiers in Immunology

allergen; allergic disease; allergy development; breastmilk; differential network analysis; immunology of human milk; immunomodulatory; milk proteome
Ezeugwu VE, Adamko D, van Eeden C, Dubeau A, Turvey SE, Moraes TJ, Simons E, Subbarao P, Wishart DS, Mandhane PJ 2022

Development of a predictive algorithm to identify pre-school children at risk for behavior changes associated with sleep-related breathing disorders
citation

Sleep Medicine

behavior changes; sleep-related breathing disorders; boruta; prediction; random forest; scoring system; urine metabolomics; snoring
Lee-Sarwar KA, Chen YC, Chen YY, Kozyrskyj AL, Mandhane PJ, Turvey SE, Subbarao P, Bisgaard H, Stokholm J, Chawes B, Sørensen SJ, Kelly RS, Lasky-Su J, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Carey VJ, Harshfield BJ, Laranjo N, Gold 2022

The maternal prenatal and offspring early-life gut microbiome of childhood asthma phenotypes
citation

Allergy

maternal prenatal gut microbiome; microbiota; asthma phenotypes; Bacteroides; cesarean delivery; C-section; metabolomics; sphingolipids; wheeze; respiratory health
Medeleanu M, Upton JEM, Reyna Vargas ME, Dai R, Mandhane PJ, Simons E, Turvey SE, Subbarao P, Moraes TJ 2022

Moderate-to-severe lower respiratory tract infection in early life is associated with increased risk of polysensitization and atopic dermatitis: Findings from the CHILD Study

Journal of Allergy and Clinical Immunology: Global

respiratory health; allergy; atopy; atopic dermatitis; eczema; food allergy; asthma
Obiakor CV, Parks J, Takaro TK, Tun HM, Morales-Lizcano N, Azad MB, Mandhane PJ, Moraes TJ, Simons E, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL. 2022

Early Life Antimicrobial Exposure: Impact on Clostridioides difficile Colonization in Infants
citation

Antibiotics (Basel)

antimicrobial exposure; Clostridioides difficile (C. dificile); antibiotics; cleaning products; gut microbiota; microbiome
Parks J, McCandless L, Dharma C, Brook J, Turvey SE, Mandhane P, Becker AB, Kozyrskyj AL, Azad MB, Moraes TJ, Lefebvre DL, Sears MR, Subbarao P, Scott J, Takaro TK 2022

Association of use of cleaning products with respiratory health in a Canadian birth cohort
citation

Canadian Medical Association Journal

household cleaning products; respiratory health; wheeze; asthma; allergic airway disease
Parks J, McLean KE, McCandless L, de Souza RJ, Brook JR, Scott J, Turvey SE, Mandhane PJ, Becker AB, Azad MB, Moraes TJ, Lefebvre DL, Sears MR, Subbarao P, Takaro TK 2022

Assessing secondhand and thirdhand tobacco smoke exposure in Canadian infants using questionnaires, biomarkers, and machine learning
citation

Journal of Exposure Science and Environmental Epidemiology

tobacco smoke exposure; machine learning; asthma; Cotinine; maternal smoking; urinary nicotine biomarkers; pregnancy
Reyna ME, Dai R, Tran MM, Breton V, Medeleanu M, Lou WYW, Foong RE, Emmerson M, Dharma C, Miliku K, Lefebvre DL, Simons E, Azad MB, Chan-Yeung M, Becker AB, Mandhane PJ, Turvey SE, Hall GL, Moraes TJ, Sears MR, Subbarao P 2022

Development of a Symptom-Based Tool for Screening of Children at High Risk of Preschool Asthma
citation

JAMA Network Open

symptom-based screening tool; asthma; asthma prediction tools; wheeze; cough; emergency department visits or hospitalizations; primary care; respiratory health
Reyna ME, Petersen C, Dai DLY, Dai R, Becker AB, Azad MB, Miliku K, Lefebvre DL, Moraes TJ, Mandhane PJ, Boutin RCT, Finlay BB, Simons E, Kozyrskyj AL, Lou W, Turvey SE, Subbarao P 2022

Longitudinal body mass index trajectories at preschool age: children with rapid growth have differential composition of the gut microbiota in the first year of life
citation

International Journal of Obesity

body mass index (BMI) trajectories; rapid growth; gut microbiota; microbiome; obesity; overweight; breastfeeding; human milk
Reyna-Vargas ME, Parmar A, Lefebvre DL, Azad MB, Becker AB, Turvey SE, Moraes TJ, Lou W, Subbarao P, Sears MR, Mandhane PJ, Narang I. 2022

Longitudinal Associations Between Sleep Habits, Screen Time and Overweight, Obesity in Preschool Children
citation

Nature and Science of Sleep

sleep habits, screen time, overweight, obesity, BMI, nocturnal sleep, bedtime
Rodriguez N, Tessier CA, Mandhane PJ, Pei J, Simons E, Moraes TJ, Turvey SE, Subbarao P, Kozyrskyj AL 2022

Sex-specific associations among infant food and atopic sensitizations and infant neurodevelopment
citation

Frontiers in Pediatrics

sex-specific, infant food, atopic sensitizations, neurodevelopment, atopy; food sensitization; infant; neurodevelopment; social-emotional development; Bayley Scales; cognitive development; mental health
Safavi S, Dai R, Breton VL, Emmerson MN, Kowalik K, Lu Z, Lou W, Dubeau A, DeLorenzo S, Azad MB, Becker AB, Mandhane PJ, Turvey SE, Gustafsson P, Lefebvre DL, Sears MR, Moraes TJ, Subbarao P 2022

Lung clearance index predicts persistence of preschool wheeze
citation

Pediatric Allergy and Immunology

lung clearance index (LCI); predictive tool; asthma; multiple breath washout; preschool; pulmonary function test; ventilation inhomogeneity; wheeze phenotypes
Sbihi H, Simmons KE, Sears MR, Moraes TJ, Becker AB, Mandhane PJ, Subbarao P, Dai DLY, Finlay BB, Turvey SE, Gantt S 2022

Early-life cytomegalovirus infection is associated with gut microbiota perturbations and increased risk of atopy
citation

Pediatric Allergy and Immunology

cytomegalovirus infection; gut microbiota; atopy; allergy; atopy; immune development; microbiome; microbiota
Tun MH, Chari R, Kaul P, Mamede FV, Paulden M, Lefebvre DL, Turvey SE, Moraes TJ, Sears MR, Subbarao P, Mandhane PJ 2022

Prediction of odds for emergency cesarean section: A secondary analysis of the CHILD term birth cohort study
citation

PLoS One

emergency cesarean section (C-section); intrapartum risk factors; predictive model; pregnancy; maternal age; BMI
Boutin RCT, Petersen C, Woodward SE, Serapio-Palacios A, Bozorgmehr T, Loo R, Chalanuchpong A, Cirstea M, Lo B, Huus KE, Barcik W, Azad MB, Becker AB, Mandhane PJ, Moraes TJ, Sears MR, Subbarao P, McNagny KM, Turvey SE, Finlay B 2021

Bacterial-fungal interactions in the neonatal gut influence asthma outcomes later in life
citation

eLife

infant gut microbiota; short-chain fatty acids (SCFAs); microbiome; allergic airway disease; asthma; bacteria; fungi
Boutin RCT, Sbihi H, McLaughlin RJ, Hahn AS, Konwar KM, Loo RS, Dai D, Petersen C, Brinkman FSL, Winsor GL, Sears MR, Moraes TJ, Becker AB, Azad MB, Mandhane PJ, Subbarao P, Turvey SE, Finlay BB 2021

Composition and Associations of the Infant Gut Fungal Microbiota with Environmental Factors and Childhood Allergic Outcomes
citation

mBio

asthma/allergy; atopy; fungi; infant immune development; microbiota; mycobiota
Chehab R, Fehr K, Moossavi S, Moraes T, Mandhane P, de Souza R, Turvey S,  Subbarao P, Khafipour E, Azad M, Forman M 2021

Maternal Prenatal Supplement Intake, but Not Dietary Patterns, Is Associated With Human Milk Microbiota Composition in the CHILD Cohort Study
citation

Current Developments in Nutrition

prenatal diet; prenatal supplement intake; human milk microbiota; pregnancy; microbiome
Chen YY, Zhao X, Moeder W, Tun HM, Simons E, Mandhane PJ, Moraes TJ, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL. 2021

Impact of Maternal Intrapartum Antibiotics, and Caesarean Section with and without Labour on Bifidobacterium and Other Infant Gut Microbiota
citation

Microorganisms

Bifidobacterium; Bifidobacterium longum subsp. infantis; breastfeeding; caesarean section; infant gut microbiota; labour; maternal intrapartum antibiotics
Chooniedass R, Tarrant M, Turner S, Lok Fan HS, Del Buono K, Masina S, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Sears MR, Subbarao P, Azad MB 2021

Factors associated with breastfeeding initiation and continuation in Canadian-born and non-Canadian-born women: a multi-centre study
citation

Public Health Nutrition

Breastfeeding continuation; Breastfeeding initiation; Canadian-born; Immigrant; Non-Canadian born
Ezeugwu VE, Mandhane PJ, Hammam N, Brook JR, Tamana SK, Hunter S, Chikuma J, Lefebvre DL, Azad MB, Moraes TJ, Subbarao P, Becker AB, Turvey SE, Rosu A, Sears MR, Carson V 2021

Influence of Neighborhood Characteristics and Weather on Movement Behaviors at Age 3 and 5 Years in a Longitudinal Birth Cohort
citation

Journal of Physical Activity and Health

accelerometry; preschool children; season
Laforest-Lapointe I, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Sears MR, Subbarao P, Sycuro LK, Azad MB, Arrieta MC 2021

Maternal consumption of artificially sweetened beverages during pregnancy is associated with infant gut microbiota and metabolic modifications and increased infant body mass index
citation

Gut Microbes

16s rRNA; BMI; gut microbiota; microbiome; artificial sweeteners; breastfeeding; genomics; gestational exposure; metabolomics; obesity
Lu Z, Dai R, Kowalik K, Dubeau A, Lefebvre DL, Balkovec S, Becker AB, Mandhane PJ, Turvey SE, Lou W, Ratjen F, Moraes TJ, Sears MR, Gustafsson PM, Subbarao P 2021

Newly developed multiple-breath washout reference equations from the CHILD Cohort Study: implications of poorly fitting equations
citation

ERJ Open Research

multiple-breath washout reference equations; Lung clearance index (LCI)
Miliku K, Moraes TJ, Becker AB, Mandhane PJ, Sears MR, Turvey SE, Subbarao P, Azad MB 2021

Breastfeeding in the First Days of Life Is Associated With Lower Blood Pressure at 3 Years of Age
citation

Journal of the American Heart Association

breastfeeding; cardiovascular disease risk; blood pressure
Miliku K, Richelle J, Becker AB, Simons E, Moraes TJ, Turvey SE, Mandhane PJ, Sears MR, Subbarao P, Field CJ, Azad MB 2021

Sex-specific associations of human milk long-chain polyunsaturated fatty acids and infant allergic conditions
citation

Pediatric Allergy and Immunology

atopic dermatitis; breastfeeding; food sensitization; human milk; polyunsaturated fatty acids
Moossavi S, Fehr K, Khafipour E, Subbarao P, Azad MB 2021

Repeatability and reproducibility assessment in a large-scale population-based microbiota study: case study on human milk microbiota
citation

Microbiome

quality control; low biomass microbiome research; human milk microbiota
Navaranjan G, Diamond ML, Harris SA, Jantunen LM, Bernstein S, Scott JA, Takaro TK, Dai R, Lefebvre DL, Azad MB, Becker MB, Mandhane PJ, Moraes TJ, Simons E, Turvey SE, Sears MR, Subbarao P, Brook JR 2021

Early life exposure to phthalates and the development of childhood asthma among Canadian children
citation

Environmental Research

asthma; phthalates; wheeze; house dust; DEHP
Navaranjan G, Jantunen LM, Diamond ML, Harris SA, Bernstein S, Scott JA, Takaro TK, Dai R, Lefebvre DL, Mandhane PJ, Moraes TJ, Simons E, Turvey SE, Sears MR, Subbarao P, Brook JR 2021

Early Life Exposure to Tris(2-butoxyethyl) Phosphate (TBOEP) Is Related to the Development of Childhood Asthma
citation

Environmental Science & Technology Letters

organophosphate esters (OPEs); asthma; wheeze; house dust
Petersen C, Dai DLY, Boutin RCT, Sbihi H, Sears MR, Moraes TJ, Becker AB, Azad MB, Mandhane PJ, Subbarao P, Turvey SE, Finlay BB 2021

A rich meconium metabolome in human infants is associated with early-life gut microbiota composition and reduced allergic sensitization
citation

Cell Reports Medicine

meconium; microbiota maturation; allergic sensitization; neonatal niche metabolome; newborn; early-life window
Rodd C, Feely A, Becker AB, Moraes TJ, Subbarao P, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR, Azad MB, Sharma A 2021

World Health Organization growth standards: How do Canadian children measure up?
citation

Paediatrics & Child Health

breastfeeding; body mass index (BMI); obesity; overweight; formula; diet; nutrition
Shanmuganathan M, Kroezen Z, Gill B, Azab S, de Souza RJ, Teo KK, Atkinson S, Subbarao P, Desai D, Anand SS, Britz-McKibbin P 2021

The maternal serum metabolome by multisegment injection-capillary electrophoresis-mass spectrometry: a high-throughput platform and standardized data workflow for large-scale epidemiological studies
citation

Nature Protocols

maternal serum metabolome; multisegment injection-capillary electrophoresis-mass spectrometry
Tamana, S. K., Tun, H. M., Konya, T., Chari, R. S., Field, C. J., Guttman, D. S., Becker, A. B., Moraes, T. J., Turvey, S. E., Subbarao, P., Sears, M. R., Pei, J., Scott, J. A., Mandhane, P. J., & Kozyrskyj, A. L. 2021

Bacteroides-dominant gut microbiome of late infancy is associated with enhanced neurodevelopment
citation

Gut Microbes

gut microbiota, neurodevelopment, cognition, bacteroidetes, early colonization
Tun HM, Peng Y, Chen B, Konya TB, Morales-Lizcano NP, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Moraes TJ, Sears MR, Turvey SE, Subbarao P, Simons E, Scott JA, Kozyrskyj AL 2021

Ethnicity associations with food sensitization are mediated by gut microbiota development in the first year of life
citation

Gastroenterology

atopy; food sensitization; infant gut; microbiota development; microbiome
Turvey SE, Lee TY, Sears MR, Becker AB, Mandhane PJ, Moraes TJ, Subbarao P, Sadatsafavi M 2021

Development of a conceptual model of childhood asthma to inform asthma prevention policies
citation

BMJ Open Respiratory Research

decision analytic models for asthma prevention; risk factors
Akhabir L, Rosenberg E, Tworek D, Heroux D, Balhara J, McNagny KM, Sears MR, Lefebvre DL, Becker AB, Turvey SE, Mandhane PJ, Moraes TJ, Subbarao P, Paré G, Denburg JA 2020

Cord Blood Hemopoietic Cell Receptor Expression is Associated with Early Life Atopic Risk and Lung Function
citation

Allergy

cord blood hemopoietic cell receptor, atopic risk, lung function, atopy, allergy, airway inflammation
Azad MB, Archibald A, Tomczyk MM, Head A, Cheung KG, de Souza RJ, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Sears MR, Subbarao P, Dolinsky VW 2020

Nonnutritive sweetener consumption during pregnancy, adiposity, and adipocyte differentiation in offspring: evidence from humans, mice, and cells
citation

International Journal of Obesity

nonnutritive sweetener; pregnancy; adiposity; obesity; weight gain
Azad MB, Dharma C, Simons E, Tran M, Reyna ME, Dai R, Becker AB, Marshall J, Mandhane PJ, Turvey SE, Moraes TJ, Lefebvre DL, Subbarao P, Sears MR. 2020

Reduced peanut sensitization with maternal peanut consumption and early peanut introduction while breastfeeding
citation

Journal of Developmental Origins of Health and Disease

breastfeeding; food allergy; lactation; peanut allergy
Boutin RCT, Sbihi H, Dsouza M, Malhotra R, Petersen C, Dai D, Sears MR, Moraes TJ, Becker AB, Azad MB, Mandhane PJ, Subbarao P*, Finlay BB, Turvey SE 2020

Mining the infant gut microbiota for therapeutic targets against atopic disease
citation

Allergy

infant gut microbiota; microbiome; atopic disease; allergy; microbes; immune development
Chan D, Becker AB, Moraes TJ, Mandhane PJ, Sears MR, Turvey SE, Subbarao P, Field CJ, Azad MB 2020

Sex-specific association of human milk hormones and asthma in the CHILD cohort
citation

Pediatric Allergy and Immunology

sex-specific; human milk hormones; asthma; breastfeeding; adipokines; leptin; insulin
de Souza RJ, Shanmuganathan M, Lamri A, Atkinson SA, Becker A, Desai D, Gupta M, Mandhane PJ, Moraes TJ, Morrison KM, Subbarao P, Teo KK, Turvey SE, Williams NC, Britz-McKibbin P, Anand SS 2020

Maternal Diet and the Serum Metabolome in Pregnancy: Robust Dietary Biomarkers Generalizable to a Multiethnic Birth Cohort
citation

Current Developments in Nutrition

maternal diet; serum metabolome; pregnancy; nutrition; dietary biomarkers; metabolomics
Drall KM, Field CJ, Haqq AM, de Souza RJ, Tun HM, Morales-Lizcano NP, Konya TB, Guttman DS, Azad MB, Becker AB, Lefebvre DL, Mandhane PJ, Moraes TJ, Sears MR, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL 2020

Vitamin D supplementation in pregnancy and early infancy in relation to gut microbiota composition and C. difficile colonization: implications for viral respiratory infections
citation

Gut Microbes

Vitamin D, supplements, milk, infant, gut microbiota, C. difficile, Megamonas, Bilophila, pregnancy, microbiome
Fehr K, Moossavi S, Sbihi H, Boutin RCT, Bode L, Robertson B, Yonemitsu C, Field CJ, Becker AB, Mandhane PJ, Sears MR, Khafipour E, Moraes TJ, Subbarao P, Finlay BB, Turvey SE, Azad MB 2020

Breastmilk Feeding Practices Are Associated with the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: the CHILD Cohort Study
citation

Cell Host & Microbe

microbiome, microbiota, breastmilk, human milk, breastfeeding, pumped milk, infantgut
Hammam N, Sadeghi D, Carson V, Tamana SK, Ezeugwu VE, Chikuma J, van Eeden C, Brook JR, Lefebvre DL, Moraes TJ, Subbarao P, Becker AB, Turvey SE, Sears MR, Mandhane PJ 2020

The relationship between machine-learning derived sleep parameters and behaviour problems in 3- and 5-year old children; results from the CHILD Cohort study
citation

Sleep

behavior problems; machine learning; sleep; sleep-disordered breathing
Kang LJ, Vu KN, Koleva PT, Field CJ, Chow A, Azad MB, Becker AB, Mandhane PJ, Moraes TJ, Sears MR, Lefebvre DL, Turvey SE, Subbarao P, Lou WYW, Scott JA, Kozyrskyj AL 2020

Maternal psychological distress before birth influences gut immunity in mid‐infancy
citation

Clinical & Experimental Allergy

maternal psychological distress; gut immunity; pregnancy; allergic disease; gut microbiome; mental health
Loewen K, Moraes TJ, Turvey SE, Mandhane PJ, Sears MR, Subbarao P, BeckerAB, Azad MB, Simons E 2020

Prenatal egg consumption and infant sensitization and allergy to egg, peanut, and cow’s milk in the CHILD Cohort
citation

Journal of Allergy and Clinical Immunology: In Practice

prenatal maternal diet, nutrition, food allergy, egg, peanut, cow’s milk, allergic sensitization
Moossavi S, Atakora F, Fehr K, Khafipour E 2020

Biological observations in microbiota analysis are robust to the choice of 16S rRNA gene sequencing processing algorithm: case study on human milk microbiota
citation

BMC Microbiology

16S rRNA gene sequencing; human milk microbiota; microbiome
Moossavi S, Fehr K, Derakhshani H, Sbihi H, Robertson B, Bode L, Brook J, Turvey SE, Moraes TJ, Becker AB, Mandhane PJ, Sears MR, Khafipour E, Subbarao P, Azad MB 2020

Human milk fungi: environmental determinants and inter-kingdom associations with milk bacteria in the CHILD Cohort Study
citation

BMC Microbiology

fungi, bacteria, gut, microbiome, micobiota, human milk
Navaranjan G, Takaro TK, Wheeler AJ, Diamond ML, Shu H, Azad MB, Becker AB, Dai R, Harris SA, Lefebvre DL, Lu Z, Mandhane PJ, McLean K, Moraes TJ, Scott JA, Turvey SE, Sears MR, Subbarao P, Brook JR 2020

Early life exposure to phthalates in the Canadian Healthy Infant Longitudinal Development (CHILD) study: a multi-city birth cohort

Journal of Exposure Science and Environmental Epidemiology

Biological monitoring; Exposure assessment; Phthalates; Socioeconomic status; Urine
Nielsen CC, Gascon M, Osornio-Vargas AR, Shier C, Guttman DS, Becker AB, Azad MB, Sears MR, Lefebvre DL, Moraes TJ, Turvey SE, Subbarao P, Takaro TK, Brook JR, Scott JA, Mandhane PJ, Tun HM, Kozyrskyj AL 2020

Natural environments in the urban context and gut microbiota in infants
citation

Environment International

Natural environments; Urban; Diversity; Gut microbiota; Infants; microbiome
Patrick DM, Sbihi H, Dai DLY, Al Mamun A, Rasali D, Rose C, Marra F, Boutin RCT, Petersen C, Stiemsma LT, Winsor GL, Brinkman FSL, Kozyrskyj AL, Azad MB, Becker AB, Mandhane PJ, Moraes TJ, Sears MR, Subbarao P, Finlay BB, Turvey SE 2020

Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies
citation

Lancet Respiratory Medicine

antibiotic use, gut microbiota, microbiome, asthma
Simard M, Madore AM, Girard S, Waserman S, Duan Q, Subbarao P, Sears MR, Moraes TJ, Becker AB, Turvey SE, Mandhane PJ, Morin C, Bégin P, Laprise C 2020

Polygenic Risk Score for Atopic Dermatitis in the Canadian Population
citation

Journal of Allergy and Clinical Immunology

Polygenic Risk Score, Atopic Dermatitis, eczema, allergy
Vézina K, Mariasine J, Young R, Reyna M, Lu Z, Subbarao P, Moraes TJ, Becker AB, Turvey SE, Sears MR, Lefebvre DL, Azad MB, Rasmussen C, Pei J, Narang I, Mandhane PJ 2020

Cardiorespiratory Monitoring Data during Sleep in One-year-old Healthy Canadian Infants
citation

Annals of the American Thoracic Society

apnea; normative values; sleep; cardiopulmonary
Vu K, Lou W, Tun HM, Konya TB, Morales-Lizcano N, Chari RS, Field CJ, Guttman DS, Mandal R, Wishart DS, Azad MB, Becker AB, Mandhane PJ, Moraes TJ, Lefebvre DL, Sears MR, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL 2020

From birth to overweight and atopic disease: multiple and common pathways of the infant gut microbiome
citation

Gastroenterology

Cesarean Birth; Gut Microbiota; Labor; Metabolites; C-section
Zulyniak MA, de Souza RJ, Shaikh M, Ramasundarahettige C, Tam K, Williams N, Desai D, Lefebvre DL, Gupta M, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Moraes T, Azad MB, Teo KK, Sears MR, Anand SS; NutriGen Alliance investigators 2020

Ethnic differences in maternal diet in pregnancy and infant eczema
citation

PLoS One

Azad MB 2019

Infant Feeding and the Developmental Origins of Chronic Disease in the CHILD Cohort: Role of Human Milk Bioactives and Gut Microbiota
citation

Breastfeeding Medicine

Infant Feeding,Human Milk Bioactives, Gut Microbiota, breastfeeding, microbiome,
Cait A, Cardenas E, Dimitriu PA, Amenyogbe N, Dai D, Cait J, Sbihi H, Stiemsma L, Subbarao P, Mandhane PJ, Becker AB, Moraes TJ, Sears MR, Lefebvre DL, Azad MB, Kollmann T, Turvey SE, Mohn WW 2019

Reduced genetic potential for butyrate fermentation in the gut microbiome of infants who develop allergic sensitization
citation

Journal of Allergy and Clinical Immunology

Atopy; butyrate; metagenome; microbiome; allergy
Carson V, Ezeugwu VE, Tamana SK, Chikuma J, Lefebvre DL, Azad MB, Moraes TJ, Subbarao P, Becker AB, Turvey SE, Sears MR, Mandhane PJ 2019

Associations between meeting the Canadian 24-Hour Movement Guidelines for the Early Years and behavioral and emotional problems among 3-year-olds
citation

Journal of Science and Medicine in Sport

Child development; Exercise; Fitness trackers; Guideline; Sleep; Television; screen time; mental health
Chen W, Subbarao P, McGihon RE, Feldman LY, Zhu J, Lou W, Gershon AS, Abdullah K, Moraes TJ, Dubeau A, Sears MR, Lefebvre DL, Turvey SE, Mandhane PJ, Azad MB, To T 2019

Patterns of health care use related to respiratory conditions in early life: A birth cohort study with linked administrative data
citation

Pediatric Pulmonology

health care use; medical costs; respiratory; lung health
Chow A, Dharma C, Chen E, Mandhane PJ, Turvey SE, Elliott SJ, Becker AB, Subbarao P, Sears MR, Kozyrskyj AL 2019

Trajectories of Depressive Symptoms and Perceived Stress From Pregnancy to the Postnatal Period Among Canadian Women: Impact of Employment and Immigration
citation

American Journal of Public Health

mental health, depression, pregnancy, postpartum, maternal, stress, socioeconomic
de Souza RJ, Zulyniak MA, Stearns JC, Wahi G, Teo K, Gupta M, Sears MR, Subbarao P, Anand SS 2019

The influence of maternal and infant nutrition on cardiometabolic traits: novel findings and future research directions from four Canadian birth cohort studies
citation

Proceedings of the Nutrition Society

nutrition, diet, FAMILY the Family Atherosclerosis Monitoring In Early Life; START the South Asian birth cohort; Birth cohort; Birth weight; Diet; Microbiome; Nutrition; Pregnancy
Drall KM, Tun HM, Morales-Lizcano NP, Konya TB, Guttman DS, Field CJ, Mandal R, Wishart DS, Becker AB, Azad MB, Lefebvre DL, Mandhane PJ, Moraes TJ, Sears MR, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL 2019

Clostridioides difficile Colonization Is Differentially Associated With Gut Microbiome Profiles by Infant Feeding Modality at 3–4 Months of Age
citation

Frontiers in Immunology

C. difficile, breastfeeding, human milk, gut microbiome, microbiota,
Krzeczkowski JE, Lau A, Fitzpatrick J, Tamana S, Smithson L, de Souza R, Kozyrskyj AL, Lefebvre D, Becker AB, Subbarao P, Turvey SE, Pei J, Schmidt LA, Sears MR, Van Lieshout RJ, Mandhane PJ; CHILD Study Investigators 2019

Maternal Metabolic Complications in Pregnancy and Offspring Behavior Problems at 2 Years of Age
citation

Maternal and Child Health Journal

Child Behavior Checklist; Gestational diabetes mellitus; Obesity; Prenatal nutrition; Prenatal programming; Preschool; pregnancy; mental health
Matenchuk BA, Tamana SK, Lou WYW, Lefebvre DL, Sears MR, Becker AB, Azad MB, Moraes TJ, Turvey SE, Subbarao P, Kozyrskyj AL, Mandhane PJ, CHILD Study investighators 2019

Prenatal Depression and Birth Mode Sequentially Mediate Maternal Education’s Influence on Infant Sleep Duration
citation

Sleep Medicine

Birth mode; Emergency caesarean section; C-section; Maternal education; Pediatric sleep; Prenatal depression; mental health
Miliku K, Duan QL, Moraes TJ, Becker AB, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR, Subbarao P, Field CJ, Azad MB 2019

Human milk fatty acid composition is associated with dietary, genetic, sociodemographic, and environmental factors in the CHILD Cohort Study
citation

American Journal of Clinical Nutrition

Human milk; fatty acids; dietary, genetic, sociodemographic, environmental factors
Moossavi S, Atakora F, Miliku K, Sepehri S, Robertson B, Duan QL, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Lefebvre DL, Sears MR, Subbarao P, Field CJ, Bode L, Khafipour E, Axad MB 2019

Integrated analysis of human milk microbiota with oligosaccharides and fatty acids in the CHILD cohort
citation

Frontiers in Nutrition

Human Milk Microbiota, Oligosaccharides, Fatty Acids, secretor status, breastfeeding practices, respiratory health
Moossavi S, Sepehri S, Robertson B, Bode L, Goruk S, Field CJ, Lix LM, de Souza R, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Moraes TJ, Lefebvre DL, Sears MR, Khafipour E, Azad MB 2019

Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors
citation

Cell Host & Microbe

breastfeeding; breastmilk; human milk; infant; microbiome; microbiota; mode of breastfeeding; nutrition
Sbihi H, Jones MJ, MacIsaac JL, Brauer M, Allen RW, Sears MR, Subbarao P, Mandhane PJ, Moraes TJ, Azad MB, Becker AB, Brook JR, Kobor MS, Turvey SE 2019

Prenatal exposure to traffic-related air pollution, the gestational epigenetic clock, and risk of early-life allergic sensitization
citation

Journal of Allergy and Clinical Immunology

prenatal maternal exposure, pregnancy, traffic-related air pollution (TRAP), gestational epigenetic clock, allergic sensitization, allergy
Simons E, Balshaw R, Lefebvre DL, Dai D, Turvey SE, Moraes TJ, MandhanePJ, Azad MB, Sears MR, Subbarao P, Becker AB 2019

Timing of Introduction, Sensitization and Allergy to Highly-Allergenic Foods at Age 3 Years in a General-Population Canadian Cohort
citation

Journal of Allergy and Clinical Immunology: In Practice

allergenic foods, food allergy, peanut, egg, cow's milk, atopy, eczema, diet
Tamana SK, Ezeugwu V, Chikuma J, Lefebvre DL, Azad MB, Moraes TJ, Subbarao P, Becker AB, Turvey SE, Sears MR, Dick BD, Carson V, Rasmussed C, CHILD Study investigators, Pei J, Mandhane PJ 2019

Screen-time is associated with inattention problems in preschoolers: Results from the CHILD birth cohort study
citation

PLOS ONE

screen-time, pre-school, inattention problems, cognitive health
Workman CE, Becker AB, Azad MB, Moraes TJ, Mandhane PJ, Turvey SE, Subbarao P, Brook JR, Sears MR, Wong CS 2019

Associations between concentrations of perfluoroalkyl substances in human plasma and maternal, infant, and home characteristics in Winnipeg, Canada
citation

Environmental Pollution

Blood; Developmental effects; Liquid chromatography; Perfluoroalkyl substances
Azad MB, Robertson B, Atakora F, Becker AB, Subbarao P, Moraes TJ, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR, Bode L 2018

Human Milk Oligosaccharide Concentrations Are Associated with Multiple Fixed and Modifiable Maternal Characteristics, Environmental Factors, and Feeding Practices
citation

The Journal of Nutrition

Human milk oligosaccharides (HMOs), Secretor status, feeding practices, environmental factors, breastfeeding
Azad MB, Vehling L, Chan D, Klopp A, Nickel NC, McGavock JM, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Taylor MS, Lefebvre DL, Sears MR, Subbarao P; CHILD Study Investigators 2018

Infant Feeding and Weight Gain: Separating Breast Milk From Breastfeeding and Formula From Food
citation

Pediatrics

breastfeeding, human milk, nutrition, bottle, formula, obesity, weight gain
Bridgman SL, Azad MB, Persaud RR, Chari RS, Becker AB, Sears MR, Mandhane PJ, Turvey SE, Subbarao P, Haqq AM, Kozyrskyj AL 2018

Impact of maternal pre-pregnancy overweight on infant overweight at 1 year of age: associations and sex-specific differences
citation

Pediatric Obesity

maternal; overweight; pregnancy; obesity; sex-specific
Chan D, Goruk S, Becker A, Subbarao P, Mandhane P, Turvey S, Lefebvre D, Sears M, CHILD Study investigators, Field C, Azad M 2018

Adiponectin, leptin and insulin in breast milk: associations with maternal characteristics and infant body composition in the first year of life
citation

International Journal of Obesity

Adiponectin, leptin, insulin, breast milk, human milk, breastfeeding, weight gain, obesity, hormones, maternal
Cusack L, Sbihi H, Larkin A, Chow A, Brook JR, Moraes T, Mandhane PJ, Becker AB, Azad MB, Subbarao P, Kozyrskyj A, Takaro TK, Sears MR, Turvey SE, Hystad P; CHILD Study Investigators 2018

Residential green space and pathways to term birth weight in the Canadian Healthy Infant Longitudinal Development (CHILD) Study
citation

International Journal of Health Geographics

Birth outcomes; Birth weight; Built environment; Green space; Nature
Dharma C, Lefebvre DL, Lu Z, Lou WYW, Becker AB, Mandhane PJ, Turvey SE, Moraes T, Azad MB, Chen E, Elliott SJ, Kozyrskyj A, Sears MR, Subbarao PJ 2018

Risk for Maternal Depressive Symptoms and Perceived Stress by Ethnicities in Canada: From Pregnancy Through the Preschool Years
citation

The Canadian Journal of Psychiatry

maternal depression, mental health, socioeconomic, ethnicity, stress
Dharma C, Lefebvre DL, Tran MM, Lou WYW, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Sears MR, The CHILD Study investigators 2018

Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: effects on allergic diseases
citation

Clinical & Experimental Allergy

allergic sensitization, atopic dermatitis, allergy, eczema, atopy, food allergy
Dharma C, Lefebvre DL, Tran MM, Lu Z, Lou WYW, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Azad MB, Sears MR; CHILD Study Investigators 2018

Diagnosing atopic dermatitis in infancy: Questionnaire reports vs criteria-based assessment
citation

Paediatric and perinatal epidemiology

accuracy; atopic dermatitis; diagnosis; eczema; epidemiology; questionnaire reports;
Forbes JD, Azad MB, Vehling L, Tun HM, Konya TB, Guttman DS, Field CJ, Lefebvre D, Sears MR, Becker AB, Mandhane PJ, Turvey SE, Moraes TJ, Subbarao P, Scott JA, Kozyrskyj AL 2018

Association of Exposure to Formula in the Hospital and Subsequent Infant Feeding Practices With Gut Microbiota and Risk of Overweight in the First Year of Life
citation

JAMA Pediatrics

infant feeding practices, gut microbiota, microbiome, risk of overweight, breastfeeding, human milk, formula, diet, nutrition
Graham C, Chooniedass R, Stefura WP, Becker AB, Sears MR, Turvey SE, Mandhane PJ, Subbarao P, CHILD Study Investigators, HayGlass KY 2018

Innate immunity acquires an anti-inflammatory bias during healthy human pregnancy: opportunities to examine links between early life environment and childhood development of allergic disorders
citation

Towards precision diagnosis and targeted intervention in allergic disease: 31st Symposium of the Collegium Internationale Allergologicum Proceedings

Innate immunity; pregnancy; environment; allergy
Kamal M, Tamana SK, Smithson L, Ding L, Lau A, Chikuma J, Mariasine J, Lefebvre DL, Subbarao P, Becker AB, Turvey SE, Sears MR, Pei J,Mandhane PJ 2018

Phenotypes of sleep-disordered breathing symptoms to two years of age based on age of onset and duration of symptoms
citation

Sleep Medicine

sleep-disordered breathing (SDB), phenotypes
Kang LJ, Koleva PT, Field CJ, Giesbrechtc GF, Wine E, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL, and CHILD Study Investigators 2018

Maternal depressive symptoms linked to reduced fecal Immunoglobulin A concentrations in infants
citation

Brain, Behavior, and Immunity

Allergy; Asthma; Birth cohort; Gut immunity; Gut microbiome; Infants; Maternal distress; Postnatal; Prenatal; Secretory Immunoglobulin A (SIgA); mental health
Lu Z, Foong R, Kowalik K, Moraes TJ, Dubeau A, Lefebvre D, Davis S, Balkovec S, Becker A, Mandhane P, Turvey S, Lou W, Sears MR, Ratjen F, Subbarao P. 2018

Reference equations for the interpretation of forced expiratory and plethysmographic measurements in infants
citation

Pediatric Pulmonology

forced flow measures; infant pulmonary function testing; plethysmography; reference equations; lung function
Lu Z, Foong RE, Kowalik K, Moraes TJ, Boyce A, Dubeau A, Balkovec S, Gustafsson PM, Becker AB, Mandhane PJ, Turvey SE, Lou W, Ratjen F, Sears M, Subbarao P 2018

Ventilation inhomogeneity in infants with recurrent wheezing
citation

Thorax

Ventilation inhomogeneity; wheeze; lung clearance index (LCI); respiratory health; lung function
Miliku K, Robertson B, Sharma AK, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR, the CHILD Study Investigators, Bode L, Azad M 2018

Human milk oligosaccharides and food sensitization among infants in the CHILD Study
citation

Allergy

Human milk oligosaccharides (HMOs); food sensitization; allergy; breastfeeding; nutrition; diet
Smithson L, Baird T, Tamana S, Lau A, Mariasine J, Chikuma J, Lefebvre DL, Subbarao P, Becker AB, Turvey SE, Sears MR, CHILD Study investigators, Beal D, Pei J, Mandhane PJ 2018

Shorter sleep duration is associated with reduced cognitive development at 2 years of age
citation

Sleep Medicine

Cognitive development; Language development; Sleep disordered breathing; Sleep duration
Tamana SK, Smithson L, Lau A, Mariasine J, Young R, Chikuma J, Lefebvre DL, Subbarao P, Becker AB, Turvey SE, Sears MR; CHILD Study Investigators, Pei J, Mandhane PJ 2018

Parent-reported symptoms of sleep disordered breathing is associated with increased behavioral problems at 2 years of age: The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study
citation

Sleep

behavior; epidemiology; infants; population-based birth cohort; sleep apnea; sleep-disordered breathing
Tran MM, Lefebvre DL, Dharma C, Dai D, Lou WYW, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Sears MR, the CHILD Study investigators 2018

Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study
citation

Journal of Allergy and Clinical Immunology

Atopic march; asthma; allergic rhinitis; food allergy; atopic dermatitis; eczema; additive interaction; multiplicative interaction
Tun HM, Bridgman SL, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL 2018

Roles of Birth Mode and Infant Gut Microbiota in Intergenerational Transmission of Overweight and Obesity From Mother to Offspring
citation

JAMA Pediatrics

birth mode, Lachnospiraceae, microbiota, infant gut microbiome, child overweight, obesity, cesarean delivery, C-section
Tun MH, Tun HM, Mahoney JJ, Konya TB, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Brook JR, Lou W, Takaro TK, Scott JA, Kozyrskyj AL; CHILD Study Investigators 2018

Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children
citation

Canadian Medical Association Journal

household disinfectants, infant gut microbiota, microbiome, overweight, obesity, cleaning products
Vehling L, Chan D, McGavock J, Becker AB, Subbarao P, Moraes TJ, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR, Azad MB 2018

Exclusive breastfeeding in hospital predicts longer breastfeeding in Canada: Implications for health equity
citation

Birth

exclusive breastfeeding, hospital, health equity
Azad MB, Vehling L, Lu Z, Dai D, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR and the CHILD Study Investigators 2017

Breastfeeding, maternal asthma and wheezing in the first year of life: a longitudinal birth cohort study
citation

European Respiratory Journal

breastfeeding; respiratory health; asthma; wheeze
Bridgman SL, Azad MB. Field CJ, Haqq AM, Becker AB, Mandhane PJ, Subbarao P, Turvey SE, Sears MR, Scott JA, Wishart DS, Kozyrskyj AL and The CHILD Study Investigators 2017

Fecal Short-Chain Fatty Acid Variations by Breastfeeding Status in Infants at 4 Months: Differences in Relative versus Absolute Concentrations
citation

Frontiers in Nutrition

gut microbiota; microbiome; short-chain fatty acids (SCFAs); breastfeeding; human milk; diet; nutrition
Graham C, Chooniedass R, Stefura WP, Becker AB, Sears MR, Turvey SE, Mandhane PJ, Subbarao P, Hayglass KT and the CHILD Study investigators 2017

In vivo immune signatures of healthy human pregnancy: Inherently inflammatory or anti-inflammatory?
citation

PLoS ONE

pregnancy, inflammatory, maternal innate immunity
Graham C, Chooniedass R, Stefura WP, Lotoski L, Lopez P, Befus AD, Becker AB, HayGlass KT 2017

Stability of pro- and anti-inflammatory immune biomarkers for human cohort studies
citation

Journal of Translational Medicine

plasma biomarkers, allergic and autoimmune inflammatory disorders
Klopp A, Vehling L, Becker AB, Subbarao P, Mandhane PJ, Turvey S, Lefebvre DL, Sears MR and the CHILD Study Investigators and Azad MB 2017

Modes of Infant Feeding and the Risk of Childhood Asthma: A Prospective Birth Cohort Study
citation

The Journal of Pediatrics

infant feeding, gut microbiome, microbiota, asthma, respiratory health, direct breastfeeding, expressed breast milk, human milk, nutrition, diet
Koleva PT, Tun HM, Konya T, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrskyj AL 2017

Sex-specific impact of asthma during pregnancy on infant gut microbiota
citation

European Respiratory Journal

sex-specific, maternal asthma, pregnancy, infant gut microbiota, microbiome, respiratory health
Stearns JC, Zulyniak MA, de Souza RJ, Campbell NC, Fontes M, Shaikh M, Sears MR, Becker AB, Mandhane PJ, Subbarao P, Turvey SE, Gupta M, Beyene J, Surrette MG, and Anand SS 2017

Ethnic and diet-related differences in the healthy infant microbiome
citation

Genome Medicine

ethnicity, diet, infant gut microbiome, microbiota, infant feeding, breastfeeding, human milk, nutrition
Tran MM, Lefebvre DL, Dai D, Dharma C, Subbarao P, Lou W, Azad MB, Becker A, Mandhane PJ, Turvey SE, Sears MR and the CHILD Study Investigators 2017

Timing of food introduction and development of food sensitization in a prospective birth cohort
citation

Pediatric Allergy and Immunology

infant feeding, food allergy, sensitization, cow's milk, egg white, peanut, alergenic foods, nutrition, diet
Tun HM, Konya T, Takaro TK, Brook JR, Chari R, Field CJ, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Scott JA, Kozyrsky AL and the CHILD Study Investigators 2017

Exposure to household furry pets influences the gut microbiota of infants at 3–4 months following various birth scenarios
citation

Microbiome

furry pets, infant gut microbiome, microbiota, pregnancy, birth mode, overweight, allergic disease, caesarean delivery, C-section, atopy, obesity
Yasmin F, Tun HM, Konya TB, Guttman DS, Chari RS, Field CJ, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, CHILD Study Investigators, Scott JA, Dinu I and Kozyrskyj AL 2017

Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy
citation

Frontiers in Pediatrics

infant gut microbiome, microbiota, caesarean delivery, C-section, food allergy, sensitization, breastfeeding, antibiotic exposure, infant feeding, diet, nutrition, formula
Zulyniak MA, de Souza RJ, Shaikh M, Shaikh M, Desai D, Lefebvre D, Gupta M, Wilson J, Wahi G, Subbarao P, Becker AB, Mandhane P, Turvey SE, Beyene J, Atkinson S, Morrison KM, McDonald S, Teo KT, Sears MR, Anand SS 2017

Does the impact of a plant-based diet during pregnancy on birth weight differ by ethnicity? A dietary pattern analysis from a prospective Canadian birth cohort alliance
citation

BMJ Open

Maternal plant-based diet, pregnancy, infant birth weight, nutrition, ethnicity
Azad MB, Konya T, Guttman DS, Charie RS, Field CJ, Sears MR, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL, CHILD Study Investigators. 2016

Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study
citation

BJOG: An International Journal of Obstetrics and Gynaecology

maternal intrapartum antibiotics, birth mode, breastfeeding, infant gut microbiota, microbiome, caesarean delivery, C-section
Azad MB, Sharma AK, de Souza R, Dolinsky VW, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Lefebvre DL, Sears MR and the CHILD Study investigators 2016

Association Between Artificially Sweetened Beverage Consumption During Pregnancy and Infant Body Mass Index
citation

JAMA Pediatrics

maternal diet, nutrition, artifical sweeteners, infant BMI, pregnancy, obesity, overweight
Bolduc FV, Lau A, Rosenfelt CS, Langer S, Wang N, Smithson L, Lefebvre D, Alexander RT, Dickson CT, Li L, Becker AB, Subbarao P, Turvey SE, Pei J, Sears MR, Mandhane PJ 2016

Cognitive enhancement in infants associated with maternal fruit intake during pregnancy: results from a birth cohort study with validation in an animal model
citation

EBio Medicine

maternal diet, nutrition, fruit, pregnancy, cognitive development, gestational diet, learning
Bridgman SL, Konya T, Azad MB, Sears MR, Becker AB, Turvey SE, Mandhane PJ, Subbarao P, CHILD Study investigators, Scott JA, Field CJ, Kozyrskyj AL 2016

Infant gut immunity: a preliminary study of IgA associations with breastfeeding
citation

Journal of Developmental Origins Health and Disease

Secretory immunoglobulin A (IgA), human milk, breastfeeding, infant gut microbiome, microbiota, allergic disease
de Souza R, Zulyniak M, Desai D, Shaikh M, Campbell N, Lefebvre D, Gupta M, Wilson J, Wahi G, Atkinson S, Teo K, Subbarao P, Becker A, Mandhane P, Turvey S, Sears M, and Anand S for the NutriGen Alliance Investigators 2016

Harmonization of Food-Frequency Questionnaires and Dietary Pattern Analysis in 4 Ethnically Diverse Birth Cohorts
citation

The Journal of Nutrition

maternal diet, nutrition, pregnancy, ethnicity, multi-cohort
Pakpour S, Scott JA, Turvey SE, Brook JR, Takaro TK, Sears MR, Klironomos J 2016

Presence of Archaea in the indoor environment and their relationship with housing characteristics
citation

Microbial Ecology

Archaea; Bacteria; Building characteristics; Human activities; Indoor environment; qPCR
Sarah L. Bridgman, Konya T, Azad MB, Guttman DS, Sears MS, Becker AB, Turvey SE, Mandhane PJ, Subbarao P, CHILD Study Investigators, Scott JA, Field CJ, Kozyrskyj AL. 2016

High fecal IgA is associated with reduced Clostridium difficile colonization in infants
citation

Microbes and Infection

C. difficile colonization, Immunoglobulin A (IgA), early gut immune development, birth mode, infant gut microbiota, microbiome
Stiemsma L, Arrieta MC, Dimitriu P, Cheng J, Thorson L, Lefebvre D, Azad MB, Subbarao P, Mandhane P, Becker A, Sears M, Kollmann T, Mohn W, Finlay B, Turvey S. 2016

Shifts in Lachnospira and Clostridium sp. In the 3-month stool microbiome are associated with preschool-age asthma
citation

Clinical Science

atopic disease, allergy, dysbiosis, infant gut microbiota, microbiome, hygiene hypothesis, microflora hypothesis, preschool age asthma, respiratory health
Subbarao P, Lu Z, Kowalik K, Brown M, Balkovec S, Gustafsson P, Lou W, Ratjen F 2016

Changes in multiple breath washout measures after raised volume rapid thoracoabdominal compression maneuvers in infants
citation

Pediatric Pulmonology

lung function, respiratory health, multiple breath inert gas washout (MBW)
Arrieta M-C, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, Kuzeljevic B, Gold MJ, Britton HM, Lefebvre DL, Subbarao P, Mandhane P, Becker A, McNagny KM, Sears MR, Kollmann T, the CHILD Study investigators, Mohn WW, Turvey SE, Finlay B 2015

Early infancy microbial and metabolic alterations in children impact risk of asthma
citation

Science Translational Medicine

asthma, allergic disease, respiratory health, infant gut microbiome, microbiota
Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, Hayglass KT, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL and the CHILD study investigators 2015

Infant gut microbiota and food sensitization: associations in the first year of life
citation

Clinical & Experimental Allergy

infant gut microbiome, microbiota, food allergy, allergic disease, atopy, sensitization
Moraes T, Lefebvre DL, Chooniedass R, Becker AB, Brook JR, Denburg J, HayGlass KT, Hegele RG, Kollmann TR, Macri J, Mandhane PJ, Scott JA, Subbarao P, Takaro TK, Turvey SE, Duncan JD, Sears MR, Befus AD, the CHILD Study Investigators. 2015

The Canadian Healthy Infant Longitudinal Development (CHILD) Study: biological samples and biobanking
citation

Paediatric and Perinatal Epidemiology

biological samples, biobanking, collecting, storing
Persaud RR, Azad MB, Chari RS, Sears MR, Becker AB, Kozyrskyj AL, the CHILD Study Investigators. 2015

Perinatal antibiotic exposure of neonates in Canada and associated risk factors: a population-based study
citation

The Journal of Maternal-Fetal & Neonatal Medicine

antibiotic; intrapartum; neonate; maternal overweight; prophylaxis
Sbihi H, Allen R, Becker A, Brook J, Mandhane P, Scott J, Sears M, Subbarao P, Takaro T, Turvey S, Brauer M 2015

Perinatal Exposure to Traffic-Related Air Pollution and Atopy at 1 Year of Age in a Multi-Center Canadian Birth Cohort Study
citation

Environmental Health Perspectives

traffic-related air pollution (TRAP), atopy, allergic disease, sensitization
Subbarao P, Anand SS, Becker AB, Befus AD, Brauer M, Brook JR, Denburg JA, HayGlass KT, Kobor MS, Kollmann TR, Kozyrskyj AL, Lou WYW, Mandhane PJ, Miller GE, Moraes TJ, Pare PD, Scott JA, Takaro TK, Turvey SE, Duncan JM, Lefebvre DL, Sears MR, et al. 2015

The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma
citation

Thorax

developmental origins of allergy, asthma and other chronic inflammatory diseases; DOHAD
Takaro TK, Scott JA, Allen RW, Anand SS, Becker AB, Befus AD, Brauer M, Duncan J, Lefebvre DL, Lou W, Mandhane PJ, McLean KE, Miller G, Sbihi H, Shu H, Subbarao P, Turvey SE, Wheeler AJ, Zeng L, Sears MR, Brook JR and the CHILD study investigators 2015

The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures
citation

Journal of Exposure Science and Environmental Epidemiology

assessment of environmental exposures; exposome; exposure profiles
Konya T, Koster B, Maughan H, Escobar M, Azad MB, Guttman D, Sears MR, Becker AB, Brook JR, Takaro TK, Kozyrskyj AL, Scott JA, the CHILD Study Investigators 2014

Associations between bacterial communities of house dust and infant gut
citation

Environmental Research

gut microbiota, gut microbiome, house dust
Maghera A, Kahlke P, Lau A, Zeng Y, Hoskins C, Corbett T, Hemmings D, Mandhane P. 2014

You are how you recruit: a cohort and randomized controlled trial of recruitment strategies
citation

BMC Medical Research Methods

recruitment, population-representative pregnancy and birth cohorts
Azad M, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker A, Scott JA, Kozyrskyj AL and CHILD Study Investigators 2013

Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity
citation

Allergy, Asthma & Clinical Immunology

Infant gut microbiota, microbiome, hygiene hypothesis, allergic disease, household pets, siblings, atopy, environmentl exposures
Azad MB, Becker AB, Guttman DS, Sears MR, Scott JA, Kozyrskyj AL, on behalf of the CHILD Study Investigators 2013

Gut microbiota diversity and atopic disease: does breastfeeding play a role?
citation

Journal of Allergy and Clinical Immunology

infant feeding, diet, nutrition, human milk, breastfeeding, gut microbiota, microbiome, atopy, allergic disease
Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, CHILD Study Investigators. 2013

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months
citation

Canadian Medical Association Journal

infant gut microbiota, microbiome, diet, nutrition, infant feding, human milk, birth mode, cesarean delivery, C-section
Lum S, Stocks J, Stanojevic S, Wade A, Robinson P, Gustafsson P, Brown M, Aurora P, Subbarao P, Hoo A-F, Sonnappa S. 2013

Age and height dependence of lung clearance index and functional residual capacity
citation

European Respiratory Journal

functional residual capacity; lung clearance index (LCI); ventilation inhomogeneity; lung function; respiratory health
Sbihi H, Brook JR, Allen RW, Curran J, Dell S, Mandhane P, Scott J, Sears MR, Subbarao P, Takaro T, Turvey SE, Wheeler A, Brauer M. 2013

A new exposure metric for traffic-related air pollution? An analysis of determinants of Hopanes in settled indoor house dust
citation

Environmental Health

traffic-related air pollution (TRAP), indoor house dust, exposure assessment, Hopanes